本文主要研究内容
作者马荣秀（2019）在《SA/PVA基气凝胶敷料的制备、抗菌及促修复作用研究》一文中研究指出：基于聚乙烯醇(PVA)和海藻酸钠(SA)无毒、可生物降解和良好的生物相容性等优点,本文以SA和PVA为原料,采用循环冻融与冻干成型的方法制备了 SA/PVA复合气凝胶。探索了循环冻融次数对其溶胀性能和降解性能的影响,对复合气凝胶的理化结构、理化性质和生物相容性进行了测试。结果表明,循环冻融3次制备的复合气凝胶具有相对较优的溶胀性能和降解性能。复合气凝胶呈三维网络结构,有利于成纤维细胞的生长增殖。随着SA含量的增加,复合气凝胶的吸水性、保水性和孔隙率均得到提高,其中PS4气凝胶的吸水率能够达到1376%,孔隙率能够达到95.1%。SA/PVA复合气凝胶的拉伸强度降低,从1.84 MPa降低至0.74 MPa。另外,SA/PVA复合气凝胶的缓慢降解速率可确保其在使用期间的稳定性。SA/PVA复合气凝胶属于非溶血性材料,具有良好的生物相容性,在伤口愈合方面具有潜在的应用价值。为了提高SA/PVA复合气凝胶的力学性能,以SA和PVA为基底原料,加入一定量的纳米纤维素(NCC),制备了 SA/NCC/PVA复合气凝胶。测试结果表明,随着NCC含量的增加,复合气凝胶的吸水性增加,孔隙率降低。与对照组相比,复合气凝胶可以将水蒸气损失率降低33.5%～38.8%。适量NCC的加入,明显改善了复合气凝胶的机械强度,与SA/PVA复合气凝胶相比,加入5 wt%的NCC之后,复合气凝胶的拉伸强度由0.93 MPa增加到1.79 MPa。载有阿莫西林(AMX)的复合气凝胶对药物的缓释性能使其对大肠杆菌(E.col)和金黄色葡萄球菌(S.aureus)均有良好的抗菌性能,能够控制伤口感染,可用作伤口敷料。为了同时改善复合气凝胶的力学性能和生物相容性,以SA和PVA为基底原料,加入一定量的氧化石墨烯(GO),制备了 SA/GO/PVA复合气凝胶。对该复合气凝胶进行了理化结构、理化性质和生物相容性等体外测试和体内伤口愈合评价。结果表明,复合气凝胶呈三维网络结构,且随着GO含量的增加,复合气凝胶的孔径逐渐减小。GO含量为0.5 wt%时,复合气凝胶的吸水率能够达到1361%。与对照组相比,GO的加入能够使复合气凝胶的水蒸气损失率降低,避免过多的水分散失,从而为伤口提供湿润的愈合环境。当GO的含量从0 wt%增加到2 wt%,复合气凝胶的拉伸强度从1.03 MPa增加到1.91 MPa,制备的复合气凝胶具有良好的强度和韧性。制备的复合气凝胶是非溶血性材料,且适量GO的加入对细胞活性有积极作用,GO含量为1 wt%的复合气凝胶在促进细胞增殖方面具有最佳效果。随着GO含量的增加,复合气凝胶对诺氟沙星(NFX)的包封率及载药量均增加,且该载药复合气凝胶对E.coli和S.aureus都有良好的抗菌效果。体内伤口愈合评价表明,载有NFX的复合气凝胶能够有效地加速伤口愈合过程,具有作为伤口敷料的潜力。
Abstract
ji yu ju yi xi chun (PVA)he hai zao suan na (SA)mo du 、ke sheng wu jiang jie he liang hao de sheng wu xiang rong xing deng you dian ,ben wen yi SAhe PVAwei yuan liao ,cai yong xun huan dong rong yu dong gan cheng xing de fang fa zhi bei le SA/PVAfu ge qi ning jiao 。tan suo le xun huan dong rong ci shu dui ji rong zhang xing neng he jiang jie xing neng de ying xiang ,dui fu ge qi ning jiao de li hua jie gou 、li hua xing zhi he sheng wu xiang rong xing jin hang le ce shi 。jie guo biao ming ,xun huan dong rong 3ci zhi bei de fu ge qi ning jiao ju you xiang dui jiao you de rong zhang xing neng he jiang jie xing neng 。fu ge qi ning jiao cheng san wei wang lao jie gou ,you li yu cheng qian wei xi bao de sheng chang zeng shi 。sui zhao SAhan liang de zeng jia ,fu ge qi ning jiao de xi shui xing 、bao shui xing he kong xi lv jun de dao di gao ,ji zhong PS4qi ning jiao de xi shui lv neng gou da dao 1376%,kong xi lv neng gou da dao 95.1%。SA/PVAfu ge qi ning jiao de la shen jiang du jiang di ,cong 1.84 MPajiang di zhi 0.74 MPa。ling wai ,SA/PVAfu ge qi ning jiao de huan man jiang jie su lv ke que bao ji zai shi yong ji jian de wen ding xing 。SA/PVAfu ge qi ning jiao shu yu fei rong xie xing cai liao ,ju you liang hao de sheng wu xiang rong xing ,zai shang kou yu ge fang mian ju you qian zai de ying yong jia zhi 。wei le di gao SA/PVAfu ge qi ning jiao de li xue xing neng ,yi SAhe PVAwei ji de yuan liao ,jia ru yi ding liang de na mi qian wei su (NCC),zhi bei le SA/NCC/PVAfu ge qi ning jiao 。ce shi jie guo biao ming ,sui zhao NCChan liang de zeng jia ,fu ge qi ning jiao de xi shui xing zeng jia ,kong xi lv jiang di 。yu dui zhao zu xiang bi ,fu ge qi ning jiao ke yi jiang shui zheng qi sun shi lv jiang di 33.5%～38.8%。kuo liang NCCde jia ru ,ming xian gai shan le fu ge qi ning jiao de ji xie jiang du ,yu SA/PVAfu ge qi ning jiao xiang bi ,jia ru 5 wt%de NCCzhi hou ,fu ge qi ning jiao de la shen jiang du you 0.93 MPazeng jia dao 1.79 MPa。zai you a mo xi lin (AMX)de fu ge qi ning jiao dui yao wu de huan shi xing neng shi ji dui da chang gan jun (E.col)he jin huang se pu tao qiu jun (S.aureus)jun you liang hao de kang jun xing neng ,neng gou kong zhi shang kou gan ran ,ke yong zuo shang kou fu liao 。wei le tong shi gai shan fu ge qi ning jiao de li xue xing neng he sheng wu xiang rong xing ,yi SAhe PVAwei ji de yuan liao ,jia ru yi ding liang de yang hua dan mo xi (GO),zhi bei le SA/GO/PVAfu ge qi ning jiao 。dui gai fu ge qi ning jiao jin hang le li hua jie gou 、li hua xing zhi he sheng wu xiang rong xing deng ti wai ce shi he ti nei shang kou yu ge ping jia 。jie guo biao ming ,fu ge qi ning jiao cheng san wei wang lao jie gou ,ju sui zhao GOhan liang de zeng jia ,fu ge qi ning jiao de kong jing zhu jian jian xiao 。GOhan liang wei 0.5 wt%shi ,fu ge qi ning jiao de xi shui lv neng gou da dao 1361%。yu dui zhao zu xiang bi ,GOde jia ru neng gou shi fu ge qi ning jiao de shui zheng qi sun shi lv jiang di ,bi mian guo duo de shui fen san shi ,cong er wei shang kou di gong shi run de yu ge huan jing 。dang GOde han liang cong 0 wt%zeng jia dao 2 wt%,fu ge qi ning jiao de la shen jiang du cong 1.03 MPazeng jia dao 1.91 MPa,zhi bei de fu ge qi ning jiao ju you liang hao de jiang du he ren xing 。zhi bei de fu ge qi ning jiao shi fei rong xie xing cai liao ,ju kuo liang GOde jia ru dui xi bao huo xing you ji ji zuo yong ,GOhan liang wei 1 wt%de fu ge qi ning jiao zai cu jin xi bao zeng shi fang mian ju you zui jia xiao guo 。sui zhao GOhan liang de zeng jia ,fu ge qi ning jiao dui nuo fu sha xing (NFX)de bao feng lv ji zai yao liang jun zeng jia ,ju gai zai yao fu ge qi ning jiao dui E.colihe S.aureusdou you liang hao de kang jun xiao guo 。ti nei shang kou yu ge ping jia biao ming ,zai you NFXde fu ge qi ning jiao neng gou you xiao de jia su shang kou yu ge guo cheng ,ju you zuo wei shang kou fu liao de qian li 。
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论文作者分别是来自东北林业大学的马荣秀，发表于刊物东北林业大学2019-11-18论文，是一篇关于海藻酸钠论文,聚乙烯醇论文,复合气凝胶论文,生物相容性论文,伤口愈合论文,东北林业大学2019-11-18论文的文章。本文可供学术参考使用，各位学者可以免费参考阅读下载，文章观点不代表本站观点，资料来自东北林业大学2019-11-18论文网站，若本站收录的文献无意侵犯了您的著作版权，请联系我们删除。
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