导读:本文包含了胃萎缩论文开题报告文献综述及选题提纲参考文献，主要关键词:炎症恶化,胃癌,萎缩性胃炎,基因表达谱
胃萎缩论文文献综述
丁西平,毛玉娣,汪朝靓,周欢,程前[1]（2019）在《胃萎缩性炎症恶变过程中基因表达谱的变化》一文中研究指出目的研究胃萎缩性炎恶变至胃癌过程中基因表达谱的变化。方法收集5例重度萎缩胃炎伴肠上皮化生组织和5例进展期胃癌组织进行基因芯片检测,筛选差异性表达的基因。通过生物信息学分析的方法对差异性表达的基因富集的生物过程、信号通路、基因编码蛋白之间相互关系进行分析。结果通过基因芯片检测,筛选出2 779个差异性表达的基因,并对变化最明显的前15个上调及前15个下调的基因进行总结,其中包括CPA2、HCAR3、BCL2A1、ITGAX等新发现的胃癌相关基因。此外,生物信息学分析显示了差异性表达基因所代表的生理意义,如炎症反应、细胞迁移、TNF信号通路、NF-kappa B信号通路、Toll样受体信号通路、趋化因子信号通路等。结论萎缩性胃炎恶变至胃癌过程中基因表达谱发生明显变化,并代表了相应的生理意义。(本文来源于《安徽医科大学学报》期刊2019年03期）
邓欢,周遵春,韩家波[2]（2008）在《“胃萎缩症”仿刺参幼体及亲参组织中病毒观察》一文中研究指出From May to June in 2006, an epidemic disease named stomach atrophy syndrome in sea cucumber Apostichopus japonicus occurred widely in Liaoning area during the hatching period. The influence area was large and mortality was high and no efficient remedy to control the development and spread of this epidemic. This epidemic occurred mainly at 5 to 7th days after larvae hatching. With the increasing of spawn times, the infected time became ahead and the larvae were diseased after being hatched 1 to 2 days. The stomach of diseased larvae shrinked gradually and the stomach wall tended to thick, rough and distorted till the stomach became nearly small globosity. In order to understand the kinds of pathogeny, the A. japonicus larvae and their parents were detected by the observations of negative stained samples and ultrathin sections. The tissue homogenate was prepared from the A. japonicus larvae and the tissue of their parents. The tissue samples were centrifuged (13 000 r·min-1, 8 min) twice after homogenizing, freezing and thawing. The supernatant solution was dripped on to a copper net and stained with 2% PTA for 5min and observed with electron microscopy. The diseased animals were also fixed in 2.5% glutaraldehyde and 1% osmium tetroxide solution. Samples were dehydrated and transferred into Epon 812 resin and then cut. Sections were stained with lead citrate and uranyl acetate and observed. The observed results showed that amount of virus particles were observed on negative staining samples in the larvae homogenate, and most of them are approximately 75-200 nm in diameter. The virus particles were also found in the gonad, body wall, the alimentary canal and the respiratory trees of corresponding parents hatched the larvae. Farther examination of larvae by electron microscopic observation of ultrathin sections showed that the virus affected mainly the connective tissue cells and epithelial cells. The virions were approximately spherical or hexagonal with envelope, and the core structures with high electron densities in the envelope were observed. The gonad, the body wall, the intestines and the respiratory tree of paternal and maternal parents were also observed by negative staining. The results showed that this kind of virion located in all the tested organs and tissues.(本文来源于《水产学报》期刊2008年02期）
邓欢,周遵春,韩家波[3]（2007）在《胃萎缩症仿刺参幼体及亲参组织中病毒的观察》一文中研究指出本文研究旨为仿刺参育苗期流行病病原种类的探索奠定基础。应用电镜技术对2006年 5-6月,辽宁地区仿刺参人工育苗期浮游幼体普遍出现一种流行病—"胃萎缩症"进行研究。该流行病波及面广,死亡率高,无有效药物控制病情的发展和蔓延。通常浮游幼体发育至大耳状后期,幼体胃逐渐收缩,胃壁增厚、粗糙、萎缩变形、最终收缩成似小球状。这种病变(本文来源于《中国海洋湖沼学会第九次全国会员代表大会暨学术研讨会论文摘要汇编》期刊2007-09-01）
Kato,S.,Nakajima,S.,Nishino,Y.,陈云茹[4]（2006）在《日本儿童中胃萎缩和幽门螺杆菌感染的相关性:一项回顾性的多中心研究》一文中研究指出The purpose of this study was to determine whether Helicobacter pylori infection and mucosal inflammation result in gastric atrophy in Japanese children. A total of 196 patients ages 1-16 years were retrospectively studied: 131 patients were infected with H. pylori and 65 patients were uninfected. Antral (n = 196) and corpus biopsy specimens (n = 70) were investigated based on the Updated Sydney system. In both the antrum and corpus, H. pylori-infected patients showed significantly higher degrees of inflammation and activity of gastritis, compared with noninfected patients. The prevalence of grade 2 or 3 atrophy in the antrum was 10.7%in H. pylori-infected patients and 0%in the noninfected patients (P < .01) and in corpus 4.3%and 0%, respectively (P = .20). The frequency of intestinal metaplasia in the 2 study groups was 4.6%and 4.6%in the antrum and 0%and 4.2%in the corpus, respectively. Among H. pylori-infected patients, the antrum showed significantly higher degrees of H. pylori density, inflammation and activity of gastritis, and atrophy than the corpus. In the antrum, atrophy was significantly correlated with activity, whereas in the corpus, atrophy correlated with H. pylori density, inflammation, and activity. H. pylori-induced gastric inflammation can cause atrophy in Japanese children, predominantly in the antrum. It remains to be determined whether H. pylori-infected children with gastric atrophy are at increased risk for gastric cancer.(本文来源于《世界核心医学期刊文摘(胃肠病学分册)》期刊2006年Z1期）
Uemura,N,杨雪娟[5]（2005）在《内镜和组织学检查在胃萎缩程度评定中的一致性》一文中研究指出Background. This study was conducted to investigate the strength of agreement between the endoscopic atrophic border(EAB) and the histological score for atrop hy. Methods.A series of 298 dyspeptic Japanese patients underwent upper endoscop y. The grade of gastric atrophy was estimated according to the EAB. Antral and c orpus biopsy specimens were taken and were evaluated semiquantitatively accordin g to the updated Sydney classification system, including the score for atrophy. The StatExact software package was used to calculate the weighted kappa statisti cs. Results. The strength of agreement between the endoscopic atrophy score (EAB ) and the histological atrophy score was good, with a weighted kappa value of 0. 51 (95%confidence interval, 0.44-0.59). Conclusions.T- he strength of agreement between the end oscopic and histological atrophy scor es is not worse than the interobserver histological agreement between two pathol ogists. It is worthwhile to carry out further research on the use of the EAB to identify and score gastric atrophy.(本文来源于《世界核心医学期刊文摘(胃肠病学分册)》期刊2005年08期）
乐凡[6]（2000）在《抑酸治疗不会导致胃萎缩》一文中研究指出有人认为,对Hp感染者进行维持性抑酸治疗会增加胃粘膜炎症活动度,促进胃腺萎缩,而且从长远来看可能促使肠腺化生、不典型增生及进一步癌变。现采用前瞻性随机对照的临床研究方法,在长期服奥美拉唑或抗反流手术的胃食管反流病人中作进一步验证。 病人和方法:具慢性胃食管反流症状,经内镜确诊为食管炎,且适合抗反流手术治疗的155例患者列为手术组,其中11例拒绝手术。(本文来源于《国外医学(消化系疾病分册)》期刊2000年01期）
[7]（1995）在《胃萎缩性变化引致癌症》一文中研究指出胃萎缩性变化引致癌症英国综合疗养院Ｄｉｘｏｎ医师最近就幽门螺杆菌（ＨＰ）感染的胃从早期到慢性期的过渡过程中组织学变化及其特征进行探讨。侵入胃的ＨＰ先潜伏在粘膜层下，附着于上皮的细胞膜，于是开始分泌各种酶及毒素，诸如来自尿素的氨所生成的尿素酶，上皮和粘...(本文来源于《山东中医杂志》期刊1995年08期）
[8]（1994）在《肠上皮化生而不是胃萎缩或胃酸缺乏是形成不利于幽门螺旋杆菌内环境的因素》一文中研究指出００５肠上皮化生而不是胃萎缩或胃酸缺乏是形成不利于幽门螺旋杆菌内环境的因素［英］／ＧｅｎｔａＲＭ…∥ＳｃａｎｄＪＧａｓｔｒｏｅｎｔｅｒｏｌ．－１９９３，２８（１０）．－９２４～９２８以往认为幽门螺旋杆菌（ＨＰ）胃炎是一种原发于胃窦部逐渐累及胃体的进展...(本文来源于《国外医学(生理、病理科学与临床分册)》期刊1994年01期）
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From May to June in 2006, an epidemic disease named stomach atrophy syndrome in sea cucumber Apostichopus japonicus occurred widely in Liaoning area during the hatching period. The influence area was large and mortality was high and no efficient remedy to control the development and spread of this epidemic. This epidemic occurred mainly at 5 to 7th days after larvae hatching. With the increasing of spawn times, the infected time became ahead and the larvae were diseased after being hatched 1 to 2 days. The stomach of diseased larvae shrinked gradually and the stomach wall tended to thick, rough and distorted till the stomach became nearly small globosity. In order to understand the kinds of pathogeny, the A. japonicus larvae and their parents were detected by the observations of negative stained samples and ultrathin sections. The tissue homogenate was prepared from the A. japonicus larvae and the tissue of their parents. The tissue samples were centrifuged (13 000 r·min-1, 8 min) twice after homogenizing, freezing and thawing. The supernatant solution was dripped on to a copper net and stained with 2% PTA for 5min and observed with electron microscopy. The diseased animals were also fixed in 2.5% glutaraldehyde and 1% osmium tetroxide solution. Samples were dehydrated and transferred into Epon 812 resin and then cut. Sections were stained with lead citrate and uranyl acetate and observed. The observed results showed that amount of virus particles were observed on negative staining samples in the larvae homogenate, and most of them are approximately 75-200 nm in diameter. The virus particles were also found in the gonad, body wall, the alimentary canal and the respiratory trees of corresponding parents hatched the larvae. Farther examination of larvae by electron microscopic observation of ultrathin sections showed that the virus affected mainly the connective tissue cells and epithelial cells. The virions were approximately spherical or hexagonal with envelope, and the core structures with high electron densities in the envelope were observed. The gonad, the body wall, the intestines and the respiratory tree of paternal and maternal parents were also observed by negative staining. The results showed that this kind of virion located in all the tested organs and tissues.
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胃萎缩论文参考文献
[1].丁西平,毛玉娣,汪朝靓,周欢,程前.胃萎缩性炎症恶变过程中基因表达谱的变化[J].安徽医科大学学报.2019
[2].邓欢,周遵春,韩家波.“胃萎缩症”仿刺参幼体及亲参组织中病毒观察[J].水产学报.2008
[3].邓欢,周遵春,韩家波.胃萎缩症仿刺参幼体及亲参组织中病毒的观察[C].中国海洋湖沼学会第九次全国会员代表大会暨学术研讨会论文摘要汇编.2007
[4].Kato,S.,Nakajima,S.,Nishino,Y.,陈云茹.日本儿童中胃萎缩和幽门螺杆菌感染的相关性:一项回顾性的多中心研究[J].世界核心医学期刊文摘(胃肠病学分册).2006
[5].Uemura,N,杨雪娟.内镜和组织学检查在胃萎缩程度评定中的一致性[J].世界核心医学期刊文摘(胃肠病学分册).2005
[6].乐凡.抑酸治疗不会导致胃萎缩[J].国外医学(消化系疾病分册).2000
[7]..胃萎缩性变化引致癌症[J].山东中医杂志.1995
[8]..肠上皮化生而不是胃萎缩或胃酸缺乏是形成不利于幽门螺旋杆菌内环境的因素[J].国外医学(生理、病理科学与临床分册).1994