本文主要研究内容
作者（2019）在《电喷雾法制备海藻酸水凝胶微马达及其磁驱动运动研究》一文中研究指出：流体电喷雾法(Hydrodynamic Electrospray Ionization Jetting Method(HESIJ))是一种可用于制备水凝胶微粒的重要方法,具有诸多优点。首先,HESIJ作为电喷雾质谱(ESI-MS)和离子迁移光谱(ESI-IMS)及其联用技术(如ESI-IMS-MS)中所采用的电离方法,已经广泛应用于分析化学领域,具有电离过程温和的特点,不会破坏需电离的待测物(如蛋白质等生物分子)。其次,HESIJ具有实验装置简单和搭建成本低的优点。最后,HESIJ在制备水凝胶颗粒或胶囊方面具有效率高的特点。在电喷雾针上施加电压并启动注射泵输送电喷雾溶液几秒钟后就可以迅速产生大量颗粒或胶囊。本论文通过优化和改进HESIJ方法,以天然高分子海藻酸盐为原料,以二价钙离子或铜离子为交联剂,以电喷雾的方式制备了海藻酸盐水凝胶颗粒和胶囊,获得了优化的HESIJ实验参数,分析了电喷雾过程中的机理。进一步,通过集成磁性纳米颗粒制备了海藻酸微马达,并实现了其磁驱动运动。本论文完成了以下研究工作:首先,针对现有HESIJ方法制备水凝胶微粒研究中的电喷雾模式较少(主要为锥注模式)以及实验参数有待优化等问题,对利用HESIJ方法制备钙交联海藻酸水凝胶微粒的滴落模式和多射流模式进行了系统的研究。研究表明,海藻酸水凝胶微粒在三种电喷雾模式(滴落、锥注和多喷射模式)、四种喷雾距离(5、10、15和20 cm)和六种喷雾浓度下显示出不同的直径和长径比。比较三种电喷雾模式,锥注模式(即双喷射模式)可以产生粒径最小、长径比最低和尺寸参数浮动最小的水凝胶微粒。对于所有电喷雾模式,当被喷雾溶液浓度≥2.5%时,形成的颗粒直径与喷涂距离是无关的。在不同的电喷雾模式和喷涂距离下,微粒的长径比差异明显。当海藻酸钠溶液浓度≤1.5%且喷雾距离为20 cm时,所有电喷雾模式所产生的微粒长径比均逐渐增大。这种现象可用链喷射效应来解释。其次,提出了超声辅助的HESIJ制备海藻酸水凝胶微粒的方法。当向液体表面喷射水凝胶时会产生表面饱和效应,形成一个不断增长的水凝胶层,直至水凝胶微粒的形成过程终止。采用超声波可以有效防止电喷雾制备水凝胶过程中的表面饱和效应。系统研究了喷涂距离、电喷雾模式、海藻酸浓度、超声频率以及对电极形状等参数对水凝胶微纳米颗粒尺寸的影响。通过在电喷雾制备过程中集成生物相容性磁性纳米颗粒成功制备了海藻酸水凝胶微马达。该微马达可以在强度为5 mT到20 mT且频率在1Hz到100 Hz的旋转磁场驱动下进行自驱运动。这些旋转的海藻酸水凝胶微马达可在溶液中进行定向运动,在磁控药物输送方面具有一定的应用潜力。然后,针对在负电位进行电喷雾操作条件下海藻酸钠易形成致密水凝胶颗粒而难以形成空心微胶囊的问题,利用低频超声辅助HESIJ方法实现了生物可降解的钙交联海藻酸水凝胶微胶囊的制备。系统的实验研究表明,海藻酸盐微胶囊的尺寸和形状与喷雾距离、电喷雾模式、电极形状和被喷雾溶液的浓度等因素是密切相关的。通过调控实验条件,成功制备了花瓶状、蘑菇状、球状等海藻酸盐微胶囊,其平均尺寸可在10μm至2 mm的区间内调控。这些微胶囊可以用于负载药物。微胶囊在负载磁性纳米粒子后可转变为海藻酸水凝胶微马达,能够在旋转磁场推动下进行定向运动。
Abstract
liu ti dian pen wu fa (Hydrodynamic Electrospray Ionization Jetting Method(HESIJ))shi yi chong ke yong yu zhi bei shui ning jiao wei li de chong yao fang fa ,ju you zhu duo you dian 。shou xian ,HESIJzuo wei dian pen wu zhi pu (ESI-MS)he li zi qian yi guang pu (ESI-IMS)ji ji lian yong ji shu (ru ESI-IMS-MS)zhong suo cai yong de dian li fang fa ,yi jing an fan ying yong yu fen xi hua xue ling yu ,ju you dian li guo cheng wen he de te dian ,bu hui po huai xu dian li de dai ce wu (ru dan bai zhi deng sheng wu fen zi )。ji ci ,HESIJju you shi yan zhuang zhi jian chan he da jian cheng ben di de you dian 。zui hou ,HESIJzai zhi bei shui ning jiao ke li huo jiao nang fang mian ju you xiao lv gao de te dian 。zai dian pen wu zhen shang shi jia dian ya bing qi dong zhu she beng shu song dian pen wu rong ye ji miao zhong hou jiu ke yi xun su chan sheng da liang ke li huo jiao nang 。ben lun wen tong guo you hua he gai jin HESIJfang fa ,yi tian ran gao fen zi hai zao suan yan wei yuan liao ,yi er jia gai li zi huo tong li zi wei jiao lian ji ,yi dian pen wu de fang shi zhi bei le hai zao suan yan shui ning jiao ke li he jiao nang ,huo de le you hua de HESIJshi yan can shu ,fen xi le dian pen wu guo cheng zhong de ji li 。jin yi bu ,tong guo ji cheng ci xing na mi ke li zhi bei le hai zao suan wei ma da ,bing shi xian le ji ci qu dong yun dong 。ben lun wen wan cheng le yi xia yan jiu gong zuo :shou xian ,zhen dui xian you HESIJfang fa zhi bei shui ning jiao wei li yan jiu zhong de dian pen wu mo shi jiao shao (zhu yao wei zhui zhu mo shi )yi ji shi yan can shu you dai you hua deng wen ti ,dui li yong HESIJfang fa zhi bei gai jiao lian hai zao suan shui ning jiao wei li de di la mo shi he duo she liu mo shi jin hang le ji tong de yan jiu 。yan jiu biao ming ,hai zao suan shui ning jiao wei li zai san chong dian pen wu mo shi (di la 、zhui zhu he duo pen she mo shi )、si chong pen wu ju li (5、10、15he 20 cm)he liu chong pen wu nong du xia xian shi chu bu tong de zhi jing he chang jing bi 。bi jiao san chong dian pen wu mo shi ,zhui zhu mo shi (ji shuang pen she mo shi )ke yi chan sheng li jing zui xiao 、chang jing bi zui di he che cun can shu fu dong zui xiao de shui ning jiao wei li 。dui yu suo you dian pen wu mo shi ,dang bei pen wu rong ye nong du ≥2.5%shi ,xing cheng de ke li zhi jing yu pen tu ju li shi mo guan de 。zai bu tong de dian pen wu mo shi he pen tu ju li xia ,wei li de chang jing bi cha yi ming xian 。dang hai zao suan na rong ye nong du ≤1.5%ju pen wu ju li wei 20 cmshi ,suo you dian pen wu mo shi suo chan sheng de wei li chang jing bi jun zhu jian zeng da 。zhe chong xian xiang ke yong lian pen she xiao ying lai jie shi 。ji ci ,di chu le chao sheng fu zhu de HESIJzhi bei hai zao suan shui ning jiao wei li de fang fa 。dang xiang ye ti biao mian pen she shui ning jiao shi hui chan sheng biao mian bao he xiao ying ,xing cheng yi ge bu duan zeng chang de shui ning jiao ceng ,zhi zhi shui ning jiao wei li de xing cheng guo cheng zhong zhi 。cai yong chao sheng bo ke yi you xiao fang zhi dian pen wu zhi bei shui ning jiao guo cheng zhong de biao mian bao he xiao ying 。ji tong yan jiu le pen tu ju li 、dian pen wu mo shi 、hai zao suan nong du 、chao sheng pin lv yi ji dui dian ji xing zhuang deng can shu dui shui ning jiao wei na mi ke li che cun de ying xiang 。tong guo zai dian pen wu zhi bei guo cheng zhong ji cheng sheng wu xiang rong xing ci xing na mi ke li cheng gong zhi bei le hai zao suan shui ning jiao wei ma da 。gai wei ma da ke yi zai jiang du wei 5 mTdao 20 mTju pin lv zai 1Hzdao 100 Hzde xuan zhuai ci chang qu dong xia jin hang zi qu yun dong 。zhe xie xuan zhuai de hai zao suan shui ning jiao wei ma da ke zai rong ye zhong jin hang ding xiang yun dong ,zai ci kong yao wu shu song fang mian ju you yi ding de ying yong qian li 。ran hou ,zhen dui zai fu dian wei jin hang dian pen wu cao zuo tiao jian xia hai zao suan na yi xing cheng zhi mi shui ning jiao ke li er nan yi xing cheng kong xin wei jiao nang de wen ti ,li yong di pin chao sheng fu zhu HESIJfang fa shi xian le sheng wu ke jiang jie de gai jiao lian hai zao suan shui ning jiao wei jiao nang de zhi bei 。ji tong de shi yan yan jiu biao ming ,hai zao suan yan wei jiao nang de che cun he xing zhuang yu pen wu ju li 、dian pen wu mo shi 、dian ji xing zhuang he bei pen wu rong ye de nong du deng yin su shi mi qie xiang guan de 。tong guo diao kong shi yan tiao jian ,cheng gong zhi bei le hua ping zhuang 、mo gu zhuang 、qiu zhuang deng hai zao suan yan wei jiao nang ,ji ping jun che cun ke zai 10μmzhi 2 mmde ou jian nei diao kong 。zhe xie wei jiao nang ke yi yong yu fu zai yao wu 。wei jiao nang zai fu zai ci xing na mi li zi hou ke zhuai bian wei hai zao suan shui ning jiao wei ma da ,neng gou zai xuan zhuai ci chang tui dong xia jin hang ding xiang yun dong 。
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论文作者分别是来自哈尔滨工业大学的，发表于刊物哈尔滨工业大学2019-12-07论文，是一篇关于电喷雾论文,水凝胶颗粒论文,水凝胶胶囊论文,微马达论文,药物负载论文,生物可降解论文,哈尔滨工业大学2019-12-07论文的文章。本文可供学术参考使用，各位学者可以免费参考阅读下载，文章观点不代表本站观点，资料来自哈尔滨工业大学2019-12-07论文网站，若本站收录的文献无意侵犯了您的著作版权，请联系我们删除。
标签：电喷雾论文; 水凝胶颗粒论文; 水凝胶胶囊论文; 微马达论文; 药物负载论文; 生物可降解论文; 哈尔滨工业大学2019-12-07论文;