本文主要研究内容
作者（2019）在《_D-Proline capped gold nanoclusters for turn-on detection of serum Raltitrexed》一文中研究指出：With _D-proline as the reducing and capping agent, fluorescent gold nanoclusters were rapidly prepared(_D-Pro@AuNCs) within 10 min at 100℃. In the present of gold nanoparticles, the fluorescence of _DPro@AuNCs was remarkably quenched. Interestingly, based on the electrostatic interaction between anticancer drug Raltitrexed and gold nanoparticles induced fluorescence "turn-on" principle, a high selective assay for detection of Raltitrexed was established with the probe associating the fluorescence emission at 435 nm. The fluorescence intensity of _D-Pro@AuNCs linearly correlated with the concentration of Raltitrexed in the range from 5.0 mmol/L to 40.0 mmol/L(R~2= 0.999) and the limit of detection was 1.9 mmol/L. Further, after Raltitrexed was abdominal injected in rats, a metabolic approach was constructed with the prepared fluorescent probe. It showed great potential of AuNCs-based sensing probes for application in analysis of serum anticancer drugs.
Abstract
With _D-proline as the reducing and capping agent, fluorescent gold nanoclusters were rapidly prepared(_D-Pro@AuNCs) within 10 min at 100℃. In the present of gold nanoparticles, the fluorescence of _DPro@AuNCs was remarkably quenched. Interestingly, based on the electrostatic interaction between anticancer drug Raltitrexed and gold nanoparticles induced fluorescence "turn-on" principle, a high selective assay for detection of Raltitrexed was established with the probe associating the fluorescence emission at 435 nm. The fluorescence intensity of _D-Pro@AuNCs linearly correlated with the concentration of Raltitrexed in the range from 5.0 mmol/L to 40.0 mmol/L(R~2= 0.999) and the limit of detection was 1.9 mmol/L. Further, after Raltitrexed was abdominal injected in rats, a metabolic approach was constructed with the prepared fluorescent probe. It showed great potential of AuNCs-based sensing probes for application in analysis of serum anticancer drugs.
论文参考文献
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：_D-Proline capped gold nanoclusters for turn-on detection of serum Raltitrexed论文
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