本文主要研究内容
作者薛霏（2019）在《一种咪鲜胺胶囊悬浮剂的制备及其性能研究》一文中研究指出：咪鲜胺（prochloraz）是由Boots Co研制、艾格福公司于1977年开发的咪唑类高效、低毒、广谱杀菌剂。对子囊菌和半知菌引起的病害防效显著,与其它种类的农药混用,也有较好的防治效果。如今市售的咪鲜胺剂型有乳油、可湿性粉剂、悬浮剂、种衣剂等。本论文拟将咪鲜胺制备成胶囊悬浮剂,旨在增强其缓释性能,提高光稳定性,延长持效期。为此,本实验从以下几方面对咪鲜胺进行了新剂型的制备和性能研究,主要研究内容和结果如下:本研究使用共沉淀法制备出纳米四氧化三铁,通过透射电镜表征可以发现制备的四氧化三铁近乎球形,粒径大约5-10 nm;并在纳米氧化铁表面成功修饰了PEI,明显提高在水中的分散性能。该材料可用于制备Pickering乳状液,使得胶囊也带有材料的优良特性。以异佛尔酮二异氰酸酯（IPDI）和PEI-Fe3O4为壁材,咪鲜胺为芯材,采用界面聚合法制备5%咪鲜胺胶囊悬浮剂。通过对制剂稳定性、胶囊粒径大小、包封率等参数的测定确定了最佳配方。其配方及制备方法是:1.将咪鲜胺溶于二甲苯中并在其中以3:2的比例加入乳化剂33#和500#以及IPDI形成油相。2.将PEI修饰氧化铁分散于少量醋酸溶液中备用。3.将油相逐渐加入水相中形成乳液。4.在乳液中加入PEI修饰氧化铁的分散溶液,并在10℃下反应6h,最后加入适量黄原胶,分散均匀后制得咪鲜胺胶囊悬浮剂。利用高效液相色谱仪,建立了咪鲜胺的液相色谱检测方法,咪鲜胺浓度与峰面积的回归方程为y=124.28x+102.11,相关系数R2=0.9997;该方法平均回收率为91.32%,在70%-110%之间;检测方法的精确度较高标准偏差为2.14,变异系数为2.2。采用生物显微镜、透射电镜、原子力显微镜、激光粒度分析仪等对5%咪鲜胺胶囊悬浮剂进行表征,结果表明:胶囊表面带有颗粒,其形状近乎球形,粒径约为101.8 nm,改变pH会影响胶囊粒径,胶囊在酸性环境下的粒径为140 nm,碱性条件下为115 nm。制剂中咪鲜胺含量约为4.87%,载药量约为30.35%,包封率约为89.01%,悬浮率约为95%,分散性优,热贮稳定性和冷贮稳定较好。咪鲜胺胶囊悬浮剂有较小的接触角和较大的黏附功,叶面展布性、润湿性良好。胶囊能明显降低咪鲜胺的光解速率,且有一定的回收潜力。实验在室内不同条件下,利用透析袋法测试了咪鲜胺胶囊悬浮剂的释放性能。通过实验发现,咪鲜胺胶囊悬浮剂具有缓释性能。胶囊在酸性环境下的释放更快,当释放介质的pH变为酸性时,胶囊存在一定的突释现象,说明胶囊对酸敏感。通过释放动力学方程的拟合,发现不同条件下的咪鲜胺胶囊悬浮剂的释放曲线与Peppas模型拟合度均为最高。不同条件下,Peppas模型中的扩散指数n均位于0.430.85之间,因此其释放机制属于Fickian扩散和骨架溶蚀。实验对5%咪鲜胺胶囊悬浮剂和25%咪鲜胺乳油在不同条件下对柑橘炭疽病菌的抑制情况进行了测定。结果显示,咪鲜胺胶囊悬浮剂的抑制率呈现一种先升高后降低的情况,其抑制率上升与药物的缓释有关,抑制率下降的原因是咪鲜胺的光解。第7天时,咪鲜胺胶囊悬浮剂的抑制率已经超过并明显高于乳油,且在酸性条件下咪鲜胺胶囊悬浮剂呈现出更高的抑制效率。说明5%咪鲜胺胶囊悬浮剂具有良好的缓释性能及防光解性能,利于增长咪鲜胺持效期,降低光解。
Abstract
mi xian an （prochloraz）shi you Boots Coyan zhi 、ai ge fu gong si yu 1977nian kai fa de mi zuo lei gao xiao 、di du 、an pu sha jun ji 。dui zi nang jun he ban zhi jun yin qi de bing hai fang xiao xian zhe ,yu ji ta chong lei de nong yao hun yong ,ye you jiao hao de fang zhi xiao guo 。ru jin shi shou de mi xian an ji xing you ru you 、ke shi xing fen ji 、xuan fu ji 、chong yi ji deng 。ben lun wen ni jiang mi xian an zhi bei cheng jiao nang xuan fu ji ,zhi zai zeng jiang ji huan shi xing neng ,di gao guang wen ding xing ,yan chang chi xiao ji 。wei ci ,ben shi yan cong yi xia ji fang mian dui mi xian an jin hang le xin ji xing de zhi bei he xing neng yan jiu ,zhu yao yan jiu nei rong he jie guo ru xia :ben yan jiu shi yong gong chen dian fa zhi bei chu na mi si yang hua san tie ,tong guo tou she dian jing biao zheng ke yi fa xian zhi bei de si yang hua san tie jin hu qiu xing ,li jing da yao 5-10 nm;bing zai na mi yang hua tie biao mian cheng gong xiu shi le PEI,ming xian di gao zai shui zhong de fen san xing neng 。gai cai liao ke yong yu zhi bei Pickeringru zhuang ye ,shi de jiao nang ye dai you cai liao de you liang te xing 。yi yi fo er tong er yi qing suan zhi （IPDI）he PEI-Fe3O4wei bi cai ,mi xian an wei xin cai ,cai yong jie mian ju ge fa zhi bei 5%mi xian an jiao nang xuan fu ji 。tong guo dui zhi ji wen ding xing 、jiao nang li jing da xiao 、bao feng lv deng can shu de ce ding que ding le zui jia pei fang 。ji pei fang ji zhi bei fang fa shi :1.jiang mi xian an rong yu er jia ben zhong bing zai ji zhong yi 3:2de bi li jia ru ru hua ji 33#he 500#yi ji IPDIxing cheng you xiang 。2.jiang PEIxiu shi yang hua tie fen san yu shao liang cu suan rong ye zhong bei yong 。3.jiang you xiang zhu jian jia ru shui xiang zhong xing cheng ru ye 。4.zai ru ye zhong jia ru PEIxiu shi yang hua tie de fen san rong ye ,bing zai 10℃xia fan ying 6h,zui hou jia ru kuo liang huang yuan jiao ,fen san jun yun hou zhi de mi xian an jiao nang xuan fu ji 。li yong gao xiao ye xiang se pu yi ,jian li le mi xian an de ye xiang se pu jian ce fang fa ,mi xian an nong du yu feng mian ji de hui gui fang cheng wei y=124.28x+102.11,xiang guan ji shu R2=0.9997;gai fang fa ping jun hui shou lv wei 91.32%,zai 70%-110%zhi jian ;jian ce fang fa de jing que du jiao gao biao zhun pian cha wei 2.14,bian yi ji shu wei 2.2。cai yong sheng wu xian wei jing 、tou she dian jing 、yuan zi li xian wei jing 、ji guang li du fen xi yi deng dui 5%mi xian an jiao nang xuan fu ji jin hang biao zheng ,jie guo biao ming :jiao nang biao mian dai you ke li ,ji xing zhuang jin hu qiu xing ,li jing yao wei 101.8 nm,gai bian pHhui ying xiang jiao nang li jing ,jiao nang zai suan xing huan jing xia de li jing wei 140 nm,jian xing tiao jian xia wei 115 nm。zhi ji zhong mi xian an han liang yao wei 4.87%,zai yao liang yao wei 30.35%,bao feng lv yao wei 89.01%,xuan fu lv yao wei 95%,fen san xing you ,re zhu wen ding xing he leng zhu wen ding jiao hao 。mi xian an jiao nang xuan fu ji you jiao xiao de jie chu jiao he jiao da de nian fu gong ,xie mian zhan bu xing 、run shi xing liang hao 。jiao nang neng ming xian jiang di mi xian an de guang jie su lv ,ju you yi ding de hui shou qian li 。shi yan zai shi nei bu tong tiao jian xia ,li yong tou xi dai fa ce shi le mi xian an jiao nang xuan fu ji de shi fang xing neng 。tong guo shi yan fa xian ,mi xian an jiao nang xuan fu ji ju you huan shi xing neng 。jiao nang zai suan xing huan jing xia de shi fang geng kuai ,dang shi fang jie zhi de pHbian wei suan xing shi ,jiao nang cun zai yi ding de tu shi xian xiang ,shui ming jiao nang dui suan min gan 。tong guo shi fang dong li xue fang cheng de ni ge ,fa xian bu tong tiao jian xia de mi xian an jiao nang xuan fu ji de shi fang qu xian yu Peppasmo xing ni ge du jun wei zui gao 。bu tong tiao jian xia ,Peppasmo xing zhong de kuo san zhi shu njun wei yu 0.430.85zhi jian ,yin ci ji shi fang ji zhi shu yu Fickiankuo san he gu jia rong shi 。shi yan dui 5%mi xian an jiao nang xuan fu ji he 25%mi xian an ru you zai bu tong tiao jian xia dui gan ju tan ju bing jun de yi zhi qing kuang jin hang le ce ding 。jie guo xian shi ,mi xian an jiao nang xuan fu ji de yi zhi lv cheng xian yi chong xian sheng gao hou jiang di de qing kuang ,ji yi zhi lv shang sheng yu yao wu de huan shi you guan ,yi zhi lv xia jiang de yuan yin shi mi xian an de guang jie 。di 7tian shi ,mi xian an jiao nang xuan fu ji de yi zhi lv yi jing chao guo bing ming xian gao yu ru you ,ju zai suan xing tiao jian xia mi xian an jiao nang xuan fu ji cheng xian chu geng gao de yi zhi xiao lv 。shui ming 5%mi xian an jiao nang xuan fu ji ju you liang hao de huan shi xing neng ji fang guang jie xing neng ,li yu zeng chang mi xian an chi xiao ji ,jiang di guang jie 。
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论文详细介绍
论文作者分别是来自西南大学的薛霏，发表于刊物西南大学2019-09-24论文，是一篇关于咪鲜胺论文,纳米氧化铁论文,胶囊论文,敏感论文,释放论文,西南大学2019-09-24论文的文章。本文可供学术参考使用，各位学者可以免费参考阅读下载，文章观点不代表本站观点，资料来自西南大学2019-09-24论文网站，若本站收录的文献无意侵犯了您的著作版权，请联系我们删除。