导读:本文包含了全身性强直一阵挛性发作论文开题报告文献综述及选题提纲参考文献，主要关键词:抗癎煎剂,癫癎,全身性强直-阵挛发作,辨证分型
全身性强直一阵挛性发作论文文献综述
张永全,谭文澜,陆晖,廖小凤[1]（2007）在《抗癎煎剂治疗全身性强直一阵挛发作型癫癎的临床研究》一文中研究指出目的:观察抗癎煎剂对全身性强直-阵挛发作型癫癎的临床疗效、中医辨证分型的疗效差异以及脑电图的改变。方法:对照组:全身性强直-阵挛发作性癫癎口服丙戊酸钠片0.2g/次,3次/日,不能控制者可加量至0.4g/次,3次/日;治疗组:全部患者均在按对照组用药基础上加用抗癎煎剂,两组均连用叁个月为一疗程,一个疗程后进行疗效评定。结果:两组总有效率比较,有显着性差异(P<0.05),治疗组优于对照组;同一证型治疗组与对照组有效率比较,风痰闭阻型非常有显着差异(P<0.01),痰火扰神,有显着性差异(P<0.05),血虚生风,心脾两虚,肝肾阴虚均无显着性差异。在改善脑电图方面治疗组亦优于对照组。结论:抗癫癎煎剂对全身性强直-阵挛发作型癫癎有较好的抗癎作用,以风痰闭阻、痰火扰神尤佳,对脑电图的改善亦优于对照组。(本文来源于《第叁届泛中医论坛·思考中医2007——中医“治未病”暨首届扶阳论坛论文集》期刊2007-12-01）
Puranam,R.S.,Jain,S.,Kleindienst,A.M.,J.O.,Mc-Namara,郭俊[2]（2006）在《全身性强直-阵挛性癫痫发作敏感基因位于染色体10q25～q26》一文中研究指出Inheritance patterns in twins and multiplex families led us to hypothesize that two loci were segregating in subjects with juvenile myoclonic epilepsy (JME), one predisposing to generalized tonic-clonic seizures (GTCS) and a second to myoclonic seizures. We tested this hypothesis by performing genomewide scan of a large family (Family 01) and used the results to guide analyses of additional families. A locus was identified in Family 01 that was linked to GTCS (10q25-q26). Model-based multipoint analysis of the 10q25-q26 locus showed a logarithm of odds (LOD) score of 2.85; similar results were obtained with model-free analyses (maximum nonparametric linkage NPL of 2.71; p = 0.0019). Analyses of the 10q25-q26 locus in 10 additional families assuming heterogeneity revealed evidence for linkage in four families; model-based and model-free analyses showed a heterogeneity LOD (HLOD) of 2.01 (α= 0.41) and maximum NPL of 2.56 (p = 0.0027), respectively, when all subjects with GTCS were designated to be affected. Combined analyses of all 11 families showed an HLOD of 4.04 (α= 0.51) and maximum NPL score of 4.20 (p = 0.000065). Fine mapping of the locus defined an interval of 4.45Mb. These findings identify a novel locus for GTCS on 10q25-q26 and support the idea that distinct loci underlie distinct seizure types within an epilepsy syndrome such as JME.(本文来源于《世界核心医学期刊文摘(神经病学分册)》期刊2006年01期）
谢圣瑞[3]（1995）在《83例全身强直一阵挛性发作癫痫临床与脑电图随访观察》一文中研究指出本文分析了８３例全身强直──阵挛性发作癫痫病人治疗前后临床与ＥＥＧ演变的随访观察资料，发现症状完全控制率以服药后前半年最高，２年完全控制率为３１．３％。病人症状好转后，ＥＥＧ也能向好的方面演变，但非线性关系。ＥＥＧ异常率的高低与临床药效无明显的对应关系，症状完全控制２年以上的病人，在减量过程中是否复发，与减量前ＥＥＧ是否异常关系不大。认为，临床上只要症状完全控制达２年以上，不必一味强调ＥＥＧ一定恢复正常，按常规给予实施减量治疗仍然是可行的。(本文来源于《赣南医学院学报》期刊1995年04期）
全身性强直一阵挛性发作论文开题报告
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Inheritance patterns in twins and multiplex families led us to hypothesize that two loci were segregating in subjects with juvenile myoclonic epilepsy (JME), one predisposing to generalized tonic-clonic seizures (GTCS) and a second to myoclonic seizures. We tested this hypothesis by performing genomewide scan of a large family (Family 01) and used the results to guide analyses of additional families. A locus was identified in Family 01 that was linked to GTCS (10q25-q26). Model-based multipoint analysis of the 10q25-q26 locus showed a logarithm of odds (LOD) score of 2.85; similar results were obtained with model-free analyses (maximum nonparametric linkage NPL of 2.71; p = 0.0019). Analyses of the 10q25-q26 locus in 10 additional families assuming heterogeneity revealed evidence for linkage in four families; model-based and model-free analyses showed a heterogeneity LOD (HLOD) of 2.01 (α= 0.41) and maximum NPL of 2.56 (p = 0.0027), respectively, when all subjects with GTCS were designated to be affected. Combined analyses of all 11 families showed an HLOD of 4.04 (α= 0.51) and maximum NPL score of 4.20 (p = 0.000065). Fine mapping of the locus defined an interval of 4.45Mb. These findings identify a novel locus for GTCS on 10q25-q26 and support the idea that distinct loci underlie distinct seizure types within an epilepsy syndrome such as JME.
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全身性强直一阵挛性发作论文参考文献
[1].张永全,谭文澜,陆晖,廖小凤.抗癎煎剂治疗全身性强直一阵挛发作型癫癎的临床研究[C].第叁届泛中医论坛·思考中医2007——中医“治未病”暨首届扶阳论坛论文集.2007
[2].Puranam,R.S.,Jain,S.,Kleindienst,A.M.,J.O.,Mc-Namara,郭俊.全身性强直-阵挛性癫痫发作敏感基因位于染色体10q25～q26[J].世界核心医学期刊文摘(神经病学分册).2006
[3].谢圣瑞.83例全身强直一阵挛性发作癫痫临床与脑电图随访观察[J].赣南医学院学报.1995
标签：抗癎煎剂; 癫癎; 全身性强直-阵挛发作; 辨证分型;