本文主要研究内容
作者（2019）在《Redox-responsive ferrocene-containing poly(ionic liquid)s for antibacterial applications》一文中研究指出：Ferrocene(Fc)-containing imidazolium type ionic liquids(ILs) and corresponding poly(ionic liquid)(PIL) membranes with tunable antibacterial activity based on electrochemical redox reaction and host-guest chemistry were developed. The effect of Fc moiety on the antimicrobial activities against both Staphylococcus aureus(S. aureus) and Escherichia coli(E. coli) was studied by minimum inhibitory concentration(MIC). The presence of Fc groups highly enhanced the antibacterial efficiency of Fccontaining ILs because of the generation of reactive oxygen species(ROS). The electrochemical oxidation of Fc to Fc+and the formation of inclusion complexes between Fc and β-CD via host-guest interactions decreased the antibacterial activities of ILs and PIL membranes. The antibacterial activities may be recovered in some extent upon the electrochemical reduction of Fc+to Fc or the exclusion of the Fc out of the cavity of β-CD. Furthermore, all the Fc-containing PIL membranes showed relatively low hemolysis activities and none cytotoxicity toward human cells, indicating clinical feasibility in topical applications.
Abstract
Ferrocene(Fc)-containing imidazolium type ionic liquids(ILs) and corresponding poly(ionic liquid)(PIL) membranes with tunable antibacterial activity based on electrochemical redox reaction and host-guest chemistry were developed. The effect of Fc moiety on the antimicrobial activities against both Staphylococcus aureus(S. aureus) and Escherichia coli(E. coli) was studied by minimum inhibitory concentration(MIC). The presence of Fc groups highly enhanced the antibacterial efficiency of Fccontaining ILs because of the generation of reactive oxygen species(ROS). The electrochemical oxidation of Fc to Fc+and the formation of inclusion complexes between Fc and β-CD via host-guest interactions decreased the antibacterial activities of ILs and PIL membranes. The antibacterial activities may be recovered in some extent upon the electrochemical reduction of Fc+to Fc or the exclusion of the Fc out of the cavity of β-CD. Furthermore, all the Fc-containing PIL membranes showed relatively low hemolysis activities and none cytotoxicity toward human cells, indicating clinical feasibility in topical applications.
论文参考文献
[1].Three-component synthesis and antibacterial evaluation of some novel 1,2-dihydroisoquinoline derivatives[J]. Sakineh Asghari,Nastaran Malekian,Roya Esmaeilpour,Mohammad Ahmadipour,Mojtaba Mohseni. Chinese Chemical Letters.2014(11)[2].Synthesis and in vitro antibacterial activities of 7-(4-alkoxyimino-3-hydroxypiperidin-1-y1)quinolone derivatives[J]. Ju Xian Wang,Qiang Guo,Yun Chai,Lian Shun Feng,Hui Yuan Guo,Ming Liang Liu~* Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China. Chinese Chemical Letters.2010(01)[3].Three antibacterial naphthoquinone analogues from cultured mycobiont of lichen Astrothelium sp[J]. Li Yan Sun~(a,b),Zhen Liang Liu~(c,*),Tao Zhang~d,Shu Bin Niu~d,Zun Tian Zhao~(b,*) a College of Pharmacology,Taishan Medical University,Taian 271016,China b College of Life Sciences,Shandong Normal University,Jinan 250014,China c College of Chemistry and Chemical Engineering,Taishan Medical University,Taian 271016,China d Key Lab of Systematic Mycology & Lichenology,Institute of Microbiology,Chinese Academy of Sciences,Beijing 100101,China. Chinese Chemical Letters.2010(07)[4].Synthesis and in vitro antibacterial activities of 7-(3-aminopyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)quinolone derivatives[J]. Xin Guo~(a,b),Yi Liang Li~(a,c),Yu Fei Liu~d,Hui Yuan Guo~a,Yu Cheng Wang~(a,*) a Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China b College of Pharmaceutical Sciences,Southwest University,Chongqing 400715,China c Tianjin Institute of Pharmaceutical Research,Tianjin Key Laboratory of Molecular Design & Drug Discovery,Tianjin 300193,China d Xuzhou Medical College,Xuzhou 221004,China. Chinese Chemical Letters.2010(10)[5].Synthesis and antibacterial activities of pleuromutilin derivatives[J]. Yuan Yuan Zhang~a,Ke Ping Xu~b,Dan Ren~c,Shao Rong Ge~c,Yu Liang Wang~(a,b,*), Yu Zhong Wang~(a,b) a Department of Chemical Engineering,Sichuan University,Chengdu 610065,China b Department of Chemistry,Sichuan University,Chengdu 610064,China C Department of Life Science,Sichuan University,Chengdu 610064,China. Chinese Chemical Letters.2009(01)[6].Synthesis and evaluation of in vitro antibacterial activity of novel 2,5-disubstituted-l,3,4-thiadiazoles from fatty acids[J]. Mudasir R.Banday,Abdul Rauf. Chinese Chemical Letters.2008(12)[7].Optimized preparation of zinc-inorganic antibacterial material containing samarium using response surface methodology[J]. 毛翠萍,张彬,唐晓宁,李欢,何素琼. Journal of Rare Earths.2014(09)[8].Synthesis and structure-activity relationship of rhodomyrtone derivatives as antibacterial agent[J]. Sukanlaya Leejae,Boon-ek Yingyongnarongkul,Apichart Suksamrarn,Supayang Piyawan Voravuthikunchai. Chinese Chemical Letters.2012(09)[9].Novel dihydropyrazole derivatives linked with multi(hetero)aromatic ring:Synthesis and antibacterial activity[J]. Lin Shan Bai~a,Yan Wang~a,Xin Hua Liu~(a,*),Hai Liang Zhu~(a,b),Bao An Song~c a Key Laboratory of Anhui Educational Department,Anhui University of Technology,Maanshan 243002,China b State Key Laboratory of Pharmaceutical Biotechnology,Nanjing University,Nanjing 210093,China c Key Laboratory of Green Pesticide and Agriculture Bioengineering,Ministry of Education,Guizhou University,Guiyang 550025,China. Chinese Chemical Letters.2009(04)[10].The Synthesis of the Reactive Antibacterial Agents and Their Antibacterial Activities[J]. 何瑾馨,朱泉,王菊生. Journal of China Textile University(English Edition).1998(04)
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：Redox-responsive ferrocene-containing poly(ionic liquid)s for antibacterial applications论文
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